4 edition of The Ocular effects of prostaglandins and other eicosanoids found in the catalog.
Includes bibliographies and index.
|Statement||editors, Laszlo Z. Bito, Johan Stjernschantz.|
|Series||Progress in clinical and biological research ;, v. 312|
|Contributions||Bito, Laszlo Z., Stjernschantz, Johan.|
|LC Classifications||QP801.P68 O28 1989|
|The Physical Object|
|Pagination||xvi, 514 p. :|
|Number of Pages||514|
|LC Control Number||89007996|
There are four families of eicosanoids—the prostaglandins, prostacyclins, the thromboxanes and the leukotrienes. These molecules react with cell receptors to produce signal transduction responses. Also, anti-inflammatory drugs and aspirin are known to reduce effects of these molecules. Hayashi M, Yablonski ME, Bito LZ. Eicosanoids as a new class of ocular hypotensive agents, II: comparison of the apparent mechanism of the ocular hypotensive effects of A and F type prostaglandins. Invest Ophthalmol Vis Sci. ;Cited by: 2.
Eicosanoids and Inflammatory Responses. As indicated in the Table below, the major actions of the series-2 prostaglandins and thromboxanes (predominantly PGE 2 and TXA 2) are pro-inflammatory as are the series-4 leukotrienes (predominantly LTB 4).Thus, it makes sense that drugs that reduce the production of these compounds would be beneficial at reducing inflammation and the associated. These prostaglandins are synthesized in the blood vessel in response to vasoconstrictors and antagonize their effects. This action protects the organ from intense vasoconstriction and maintains nutritive blood flow. They also inhibit gastric acid secretion and may exert other cellular protective effects. In their absence, gastric ulcers develop.
Bito LZ, Camras CB, Glenwood GG, Resul B () The ocular hypotensive effects and side effects of prostaglandins on the eyes of experimental animals. In: Bito LZ, Stjernschantz J (eds) The ocular effects of prostaglandins and other eicosanoids. Alan R. Liss, Inc, New York, pp – Google ScholarAuthor: S. M. Podos, C. B. Camras. This slide introduces the major mediator classes and biosynthetic pathways. Release of arachidonic acid 62 from membrane phospholipids by cytoplasmic phospholipase A 2 (cPLA 2) feeds cyclooxygenases 1 and 2 (Cox-1, Cox-2).These enzymes both form prostaglandin H 2, which is then converted to other prostaglandins and to thromboxanes by specific synthases downstream.
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Prog Clin Biol Res. ; The ocular effects of prostaglandins and other eicosanoids. [No authors listed] PMID: [PubMed - indexed for MEDLINE].
THE POTENTIAL USE OF PROSTAGLANDINS AND OTHER EICOSANOIDS IN OCULAR THERAPEUTICS A Physiological Approach to Glaucoma Management: The Use of Local Hormones and the Pharmacokinetics of Prostaglandin Esters Laszlo Z. Bito The Ocular Hypotensive Effects and Side Effects of Prostaglandins on the Eyes of Experimental Animals.
Therapeutic Overview. The term eicosanoid is used to represent a large family of endogenous compounds containing oxygenated unsaturated carbon fatty acids and includes the prostaglandins (PGs), thromboxanes (TXs), and leukotrienes (LTs).
The name PG was derived from the gland from which these compounds were first isolated, and the LTs derive their name from white blood cells and. Marks, G. Fürstenberger (Eds.) Prostaglandins, Leukotrienes, and Other Eicosanoids From Biogenesis to Clinical Application Eicosanoids - derivatives of polyunsaturated fatty acids which are primarily formed along oxidative pathways - constitute one of the most abundant and prominent family of signaling compounds which play a key role in intracellular : Hardcover.
Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, 20 carbon units in length.
Eicosanoids are a sub-category of oxylipins, i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished from other oxylipins by their overwhelming.
Biosynthesis of Prostaglandins. Prostaglandins and thromboxane A 2 (TXA 2), collectively termed prostanoids, are formed when arachidonic acid (AA), a carbon unsaturated fatty acid, is released from the plasma membrane by phospholipases (PLAs) and metabolized by the sequential actions of prostaglandin G/H synthase, or cyclooxygenase (COX), and respective by: Prostaglandins are acidic lipids which can be enzymatically produced by most mammalian cell types in response to mechanical, chemical or immunological stimuli.
The unsaturated fatty acid arachidonic acid is the precursor for the synthesis of the major classes of prostaglandins and leukotrienes, collectively known as. Prostaglandins “adverse” effects: They are involved, as well as many other compounds, transmitters and cytokines, in inflammatory reactions.
They have an algesic, nociceptive action. In sensitive terminations, prostaglandins PGE2, PGI2 have a nociceptive effect. They are involved in fever. High-Yield Terms. Eicosanoids: a family of bioactive lipids derived via the oxidation of carbon omega-3 or omega-6 polyunsaturated fatty acids, such as prostaglandins, thromboxanes, and leukotrienes Cyclic pathway: describes the pathway, initiated by prostaglandin G/H synthase, PGS (also called prostaglandin endoperoxide synthetase), for the synthesis of arachidonic acid-derived eicosanoids.
Start studying Prostaglandins. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The Ocular Effects of Prostaglandins and Other Eicosanoids, with Stjernschantz J (Eds), Alan R. Liss, New York, Ocular Effects of Prostaglandins and Other Eicosanoids (Ed), Special Supplement based on the 9th International PG Symposium (Fort Lauderdale, Florida, 12–13 May ) and the ARVO SIG Sessions on Latanoprost (Fort Lauderdale.
The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds. Emer M. Smyth, PhD, & Garret A. FitzGerald, MD. The eicosanoids are oxygenation products of polyunsaturated long-chain fatty acids. They are ubiquitous in the animal kingdom and are also found—together with their precursors—in a variety of plants.
The prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids having diverse hormone-like effects in glandins have been found in almost every tissue in humans and other animals.
They are derived enzymatically from the fatty acid arachidonic acid. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. Prostaglandins are hormones that are produced, released, and effective locally; such agents are called autocoids.
The prostaglandins are members of a family of substances called eicosanoids, which also include, among others, prostacyclin, thromboxane, and leukotrienes. Prostaglandin was first identified in seminal fluid in the s. Accordingly, renal prostaglandins should also protect the kidney from the effects of non-NSAI drug or disease-induced renal damage.
In recent years other metabolites of arachidonic acid have been discovered with a wide range of biological by: Other possible effects of prostaglandins are the eyes becoming red, irritated, puffy, or itchy due to allergy. Allergic itching goes on all day and its redness and swelling often include the eyelid skin.
While it does happen with prostaglandins, allergy is infrequent. The eicosanoids derived from these fatty acids have a variety of effects on your body. For example, they play a role in inflammation, fever promotion, blood pressure regulation, and blood clotting.
Produce less potent prostaglandins and leukotrienes The activation of phospholipase A2 releases eicosapentaenoic acid from the sn-2 position of phospholipids, which are metabolized to less potent prostaglandins PGE3 and leukotriene B5. The synthesis of the potent vasoconstrictive TXA2 is reduced and replaced TXA3.
Pathway of biosynthesis of eicosanoids from arachidonic acid, and drugs used to prevent their effects. Cyclooxygenase & Drugs Affecting the Prostanoid Pathway Cyclooxygenase (COX) is an enzyme that catalyzes the rate-determining step in the conversion of arachidonic acid to prostanoids by a 2-step process involving oxygen (Figure 2).
Prostaglandins (PGs) are ubiquitous compounds found throughout the body, including the eye. They are involved in a variety of ocular functions, two of which are intraocular pressure (IOP.The cyclooxygenase enzymes are the best known targets of NSAIDs; this diverse class of compounds blocks conversion of arachidonic acid to prostanoids.
Prostaglandins and other eicosanoids derived from COX-1 and COX-2 are involved in a variety of physiologic and pathologic processes in the gastrointestinal by: EICOSANOIDS 1.
Dr. D. K. Brahma Associate Professor Department of Pharmacology NEIGRIHMS, Shillong 2. Prostaglandins and Leukotrienes • Prostaglandins (PGs) and Leukotrienes (LTs): Biologically active 20 carbon atom polyunsaturated essential fatty acids released from cell membrane fatty acids – lipid derived autacoids • Eicosanoids: PG, Thromboxanes (TX) and LTs - .